UA researchers say molecule in cannabis could 'make pain relief higher' for cancer patients
A new study tested benefits of terpenes, component that gives plants taste and smell. The study discusses how they compare as pain relief vs. opioids. Researchers from the University of Arizona's College of Medicine-Tucson have found a breakthrough in pain relief for cancer patients. The researchers used specific molecules in cannabis to investigate the potential benefits of these molecules. They tested five terpenes to reduce pain at comparable levels to morphine and found they also blocked the 'addiction potential' of opioids when mixed with terphenes. The research is still in an early stage, but scientists hope to start a human trial sooner due to terpen being considered food and not requiring FDA approval. Researchers also hope that if the federal government removes cannabis from the strictest Schedule 1 category, scientists will have easier access to cannabis samples.
게시됨 : 10개월 전 ~에 의해 José Zozaya, By: José Zozaya ~에 Health
TUCSON, Ariz. (KGUN) — A team of researchers at the University of Arizona's College of Medicine-Tucson thinks they've found a breakthrough in pain relief for cancer patients.
KGUN 9 visited John Streicher, PhD, a lead member of the research team working on campus. Streicher, a professor and pharmacologist, helped the team look deeper into the potential benefit of some specific molecules in cannabis.
Older studies tried to look at how THC and CBD, the cannabinoids in the cannabis plant, would help manage the kind of numbing, shooting kind of nerve pain that comes as a side effect of taking chemotherapy drugs.
Past research showed that while THC and CBD did give people some moderate relief, their use also gave subjects unwanted psychoactive side effects that change someone's mood or behavior.
That's why the team from the Comprehensive Center for Pain and Addiction wanted to try an alternative with terpenes.
Streicher said you may not know that exact word, but you've smelled and tasted terpenes before.
"That kind of nice, lemony smell from a fresh lemon -- that's d-limonine, that's a terpene," Streicher said. "The smell of pine in the air when you're walking through a pine forest, that's beta-pinene that's found in pine trees."
"What wasn't appreciated until a little bit more recently," he also said, "is that these molecules also might have a therapeutic benefit, a pharmacological benefit."
The research team, Streicher said, wanted to test five cannabis terpenes. Worth noting, because the scientific testing is still in an early stage — scientists compared how mice would respond to terpene therapy versus receiving morphine for their chemotherapy-induced pain.
The big takeaway: Each terpene helped reduce pain at comparable levels to morphine. Streicher said of all the methods they tried in the testing, the best delivery method is through injection.
The research team was also pleased to find terpenes could offer another benefit: They blocked what Streicher called the 'addiction potential' of opioids, when they were mixed with terpenes as a medicine.
"Making the pain relief higher, the addiction potential lower," he said, "the idea would be maybe we can make a combined therapy with these two drugs together that are going to be highly effective for managing pain while blocking and reducing that addiction liability."
Streicher said one advantage researchers in Tucson will have to start a human trial sooner, is that terpenes are considered food. Therefore, they wouldn't be deemed a new drug that requires FDA approval.
Streicher said he's also hopeful if, or when, the federal government moves cannabis out of the strictest Schedule 1 category, that scientists will then have easier access to cannabis samples.
주제: Social Issues, Cannabis, Data